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No molecule in a living organism exists in a vacuum. Indeed, each interacts with thousands of other molecules, and the functions associated with each gene product are influenced by surrounding proteins, metabolites, and other molecules. The existence of complex pathways governing phenotypes poses a substantial challenge in efforts to diagnose complex diseases, unravel their causes, and to develop effective therapeutics.

The Lewis lab uses systems biology approaches to make sense of these complex pathways to develop network-based diagnostics for childhood disorders and to understand the regulation and activity of complex pathways, such as metabolism, protein synthesis/secretion, and glycosylation